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3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin. / Fishman, Veniamin; Battulin, Nariman; Nuriddinov, Miroslav; Maslova, Antonina; Zlotina, Anna; Strunov, Anton; Chervyakova, Darya; Korablev, Alexey; Serov, Oleg; Krasikova, Alla.

In: Nucleic Acids Research, Vol. 47, No. 2, 25.01.2019, p. 648-665.

Research output: Contribution to journal › Article › peer-review

Harvard

Fishman, V, Battulin, N, Nuriddinov, M, Maslova, A, Zlotina, A, Strunov, A, Chervyakova, D, Korablev, A, Serov, O & Krasikova, A 2019, '3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin', Nucleic Acids Research, vol. 47, no. 2, pp. 648-665. https://doi.org/10.1093/nar/gky1103

APA

Fishman, V., Battulin, N., Nuriddinov, M., Maslova, A., Zlotina, A., Strunov, A., Chervyakova, D., Korablev, A., Serov, O., & Krasikova, A. (2019). 3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin. Nucleic Acids Research, 47(2), 648-665. https://doi.org/10.1093/nar/gky1103

Vancouver

Fishman V, Battulin N, Nuriddinov M, Maslova A, Zlotina A, Strunov A et al. 3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin. Nucleic Acids Research. 2019 Jan 25;47(2):648-665. https://doi.org/10.1093/nar/gky1103

Author

Fishman, Veniamin ; Battulin, Nariman ; Nuriddinov, Miroslav ; Maslova, Antonina ; Zlotina, Anna ; Strunov, Anton ; Chervyakova, Darya ; Korablev, Alexey ; Serov, Oleg ; Krasikova, Alla. / 3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin. In: Nucleic Acids Research. 2019 ; Vol. 47, No. 2. pp. 648-665.

BibTeX

@article{9c06213d03944142aae855d3e45a8ed7,
title = "3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin",
abstract = "How chromosomes are folded, spatially organized and regulated in three dimensions inside the cell nucleus are among the longest standing questions in cell biology. Genome-wide chromosome conformation capture (Hi-C) technique allowed identifying and characterizing spatial chromatin compartments in several mammalian species. Here, we present the first genome-wide analysis of chromatin interactions in chicken embryonic fibroblasts (CEF) and adult erythrocytes. We showed that genome of CEF is partitioned into topologically associated domains (TADs), distributed in accordance with gene density, transcriptional activity and CTCF-binding sites. In contrast to mammals, where all examined somatic cell types display relatively similar spatial organization of genome, chicken erythrocytes strongly differ from fibroblasts, showing pronounced A- and B- compartments, absence of typical TADs and formation of long-range chromatin interactions previously observed on mitotic chromosomes. Comparing mammalian and chicken genome architectures, we provide evidence highlighting evolutionary role of chicken TADs and their significance in genome activity and regulation.",
keywords = "Animals, Cell Nucleus/genetics, Chickens/genetics, Chromatin/ultrastructure, Erythrocytes/ultrastructure, Evolution, Molecular, Fibroblasts/ultrastructure, Genome, PROTEIN, TRANSCRIPTION, CTCF, MODEL, IDENTIFICATION, CHROMOSOME EVOLUTION, ORDER, GENE, BIRDS, REVEALS",
author = "Veniamin Fishman and Nariman Battulin and Miroslav Nuriddinov and Antonina Maslova and Anna Zlotina and Anton Strunov and Darya Chervyakova and Alexey Korablev and Oleg Serov and Alla Krasikova",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",
year = "2019",
month = jan,
day = "25",
doi = "10.1093/nar/gky1103",
language = "English",
volume = "47",
pages = "648--665",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - 3D organization of chicken genome demonstrates evolutionary conservation of topologically associated domains and highlights unique architecture of erythrocytes' chromatin

AU - Fishman, Veniamin

AU - Battulin, Nariman

AU - Nuriddinov, Miroslav

AU - Maslova, Antonina

AU - Zlotina, Anna

AU - Strunov, Anton

AU - Chervyakova, Darya

AU - Korablev, Alexey

AU - Serov, Oleg

AU - Krasikova, Alla

N1 - Publisher Copyright: © The Author(s) 2018.

PY - 2019/1/25

Y1 - 2019/1/25

N2 - How chromosomes are folded, spatially organized and regulated in three dimensions inside the cell nucleus are among the longest standing questions in cell biology. Genome-wide chromosome conformation capture (Hi-C) technique allowed identifying and characterizing spatial chromatin compartments in several mammalian species. Here, we present the first genome-wide analysis of chromatin interactions in chicken embryonic fibroblasts (CEF) and adult erythrocytes. We showed that genome of CEF is partitioned into topologically associated domains (TADs), distributed in accordance with gene density, transcriptional activity and CTCF-binding sites. In contrast to mammals, where all examined somatic cell types display relatively similar spatial organization of genome, chicken erythrocytes strongly differ from fibroblasts, showing pronounced A- and B- compartments, absence of typical TADs and formation of long-range chromatin interactions previously observed on mitotic chromosomes. Comparing mammalian and chicken genome architectures, we provide evidence highlighting evolutionary role of chicken TADs and their significance in genome activity and regulation.

AB - How chromosomes are folded, spatially organized and regulated in three dimensions inside the cell nucleus are among the longest standing questions in cell biology. Genome-wide chromosome conformation capture (Hi-C) technique allowed identifying and characterizing spatial chromatin compartments in several mammalian species. Here, we present the first genome-wide analysis of chromatin interactions in chicken embryonic fibroblasts (CEF) and adult erythrocytes. We showed that genome of CEF is partitioned into topologically associated domains (TADs), distributed in accordance with gene density, transcriptional activity and CTCF-binding sites. In contrast to mammals, where all examined somatic cell types display relatively similar spatial organization of genome, chicken erythrocytes strongly differ from fibroblasts, showing pronounced A- and B- compartments, absence of typical TADs and formation of long-range chromatin interactions previously observed on mitotic chromosomes. Comparing mammalian and chicken genome architectures, we provide evidence highlighting evolutionary role of chicken TADs and their significance in genome activity and regulation.

KW - Animals

KW - Cell Nucleus/genetics

KW - Chickens/genetics

KW - Chromatin/ultrastructure

KW - Erythrocytes/ultrastructure

KW - Evolution, Molecular

KW - Fibroblasts/ultrastructure

KW - Genome

KW - PROTEIN

KW - TRANSCRIPTION

KW - CTCF

KW - MODEL

KW - IDENTIFICATION

KW - CHROMOSOME EVOLUTION

KW - ORDER

KW - GENE

KW - BIRDS

KW - REVEALS

UR - https://academic.oup.com/nar/advance-article-abstract/doi/10.1093/nar/gky1103/5173667

UR - http://www.mendeley.com/research/3d-organization-chicken-genome-demonstrates-evolutionary-conservation-topologically-associated-domai

UR - http://www.scopus.com/inward/record.url?scp=85060621407&partnerID=8YFLogxK

U2 - 10.1093/nar/gky1103

DO - 10.1093/nar/gky1103

M3 - Article

C2 - 30418618

VL - 47

SP - 648

EP - 665

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 2

ER -

ID: 35969559