TAAR5 (trace amine-associated receptor 5) agonist systemic administration at a dose of 10 mg/kg induces a significant increase of anxiety and grooming duration 30 min after the drug administration compared with control animals. Locomotion and exploratory activities are significantly reduced. Locomotion, motor and exploratory behaviors come back to normal after 48 hours, while anxiety is still elevated. The agonist has not affected the social preference in the friend-foe test.