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Цис-элементрегуляции транскрипции (GCC)8в 5’-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека. / Kuteikin-Teplyakov, K. B.; Orlov, S. V.; Dizhe, E. B.; Perevozchikov, A. P.

In: Bulletin of Experimental Biology and Medicine, Vol. 135, No. 5, 05.2003, p. 470-474.

Research output: Contribution to journal › Article › peer-review

Harvard

Kuteikin-Teplyakov, KB, Orlov, SV, Dizhe, EB & Perevozchikov, AP 2003, 'Цис-элементрегуляции транскрипции (GCC)8в 5’-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека', Bulletin of Experimental Biology and Medicine, vol. 135, no. 5, pp. 470-474. https://doi.org/10.1023/A:1024971526934

APA

Kuteikin-Teplyakov, K. B., Orlov, S. V., Dizhe, E. B., & Perevozchikov, A. P. (2003). Цис-элементрегуляции транскрипции (GCC)8в 5’-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека. Bulletin of Experimental Biology and Medicine, 135(5), 470-474. https://doi.org/10.1023/A:1024971526934

Vancouver

Kuteikin-Teplyakov KB, Orlov SV, Dizhe EB, Perevozchikov AP. Цис-элементрегуляции транскрипции (GCC)8в 5’-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека. Bulletin of Experimental Biology and Medicine. 2003 May;135(5):470-474. https://doi.org/10.1023/A:1024971526934

Author

Kuteikin-Teplyakov, K. B. ; Orlov, S. V. ; Dizhe, E. B. ; Perevozchikov, A. P. / Цис-элементрегуляции транскрипции (GCC)8в 5’-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека. In: Bulletin of Experimental Biology and Medicine. 2003 ; Vol. 135, No. 5. pp. 470-474.

BibTeX

@article{cf248145d4f643cf92939fea7c386ee4,
title = "Цис-элементрегуляции транскрипции (GCC)8в 5{\textquoteright}-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека",
abstract = "The 5'-untranslated region of very-low-density lipoprotein (VLDL) receptor gene includes 2 groups of triplet repeats (GCC)n. Four repeats are localized near the promoter region in position 15⋯23 from the transcription initiation site. Eight repeats were detected in position 573⋯597. Sequence (GCC)8 in VLDL receptor gene forms specific complexes with nuclear proteins of HepG2 cells, the formation of these complexes depended on Zn2+. Superexpression of the CGGBP-20 protein interacting with long sequences (GCC)n suppressed transcriptional activity of VLDL receptor gene. Removal of fragment (397⋯616) containing cis-element (GCC)8 from the 5′-untranslated region of VLDL receptor gene led to activation of the linked marker gene cat in Hutu80 cells, but did not abolish the represser effect of CGGBP-20 protein. Our results suggest that (GCC)n-binding proteins differing from CGGBP-20 regulate activity of the VLDL receptor gene via cis-element (GCC)8.",
keywords = "Cis-element, DNA-binding proteins, Gene for very-low-density lipoprotein receptor, Triplet repeats GCC",
author = "Kuteikin-Teplyakov, {K. B.} and Orlov, {S. V.} and Dizhe, {E. B.} and Perevozchikov, {A. P.}",
year = "2003",
month = may,
doi = "10.1023/A:1024971526934",
language = "English",
volume = "135",
pages = "470--474",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer Nature",
number = "5",

}

RIS

TY - JOUR

T1 - Цис-элементрегуляции транскрипции (GCC)8в 5’-нетранслируемой области генарецептора липопротеидов очень низкойплотности человека

AU - Kuteikin-Teplyakov, K. B.

AU - Orlov, S. V.

AU - Dizhe, E. B.

AU - Perevozchikov, A. P.

PY - 2003/5

Y1 - 2003/5

N2 - The 5'-untranslated region of very-low-density lipoprotein (VLDL) receptor gene includes 2 groups of triplet repeats (GCC)n. Four repeats are localized near the promoter region in position 15⋯23 from the transcription initiation site. Eight repeats were detected in position 573⋯597. Sequence (GCC)8 in VLDL receptor gene forms specific complexes with nuclear proteins of HepG2 cells, the formation of these complexes depended on Zn2+. Superexpression of the CGGBP-20 protein interacting with long sequences (GCC)n suppressed transcriptional activity of VLDL receptor gene. Removal of fragment (397⋯616) containing cis-element (GCC)8 from the 5′-untranslated region of VLDL receptor gene led to activation of the linked marker gene cat in Hutu80 cells, but did not abolish the represser effect of CGGBP-20 protein. Our results suggest that (GCC)n-binding proteins differing from CGGBP-20 regulate activity of the VLDL receptor gene via cis-element (GCC)8.

AB - The 5'-untranslated region of very-low-density lipoprotein (VLDL) receptor gene includes 2 groups of triplet repeats (GCC)n. Four repeats are localized near the promoter region in position 15⋯23 from the transcription initiation site. Eight repeats were detected in position 573⋯597. Sequence (GCC)8 in VLDL receptor gene forms specific complexes with nuclear proteins of HepG2 cells, the formation of these complexes depended on Zn2+. Superexpression of the CGGBP-20 protein interacting with long sequences (GCC)n suppressed transcriptional activity of VLDL receptor gene. Removal of fragment (397⋯616) containing cis-element (GCC)8 from the 5′-untranslated region of VLDL receptor gene led to activation of the linked marker gene cat in Hutu80 cells, but did not abolish the represser effect of CGGBP-20 protein. Our results suggest that (GCC)n-binding proteins differing from CGGBP-20 regulate activity of the VLDL receptor gene via cis-element (GCC)8.

KW - Cis-element

KW - DNA-binding proteins

KW - Gene for very-low-density lipoprotein receptor

KW - Triplet repeats GCC

UR - http://www.scopus.com/inward/record.url?scp=0242363682&partnerID=8YFLogxK

U2 - 10.1023/A:1024971526934

DO - 10.1023/A:1024971526934

M3 - Article

C2 - 12910288

AN - SCOPUS:0242363682

VL - 135

SP - 470

EP - 474

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -

ID: 91967128