CO₂ spatial and temporal variability in five Russian regions has been analyzed on the basis of OCO-2 satellite measurements (more than 300 days during 4.5 years, more than 50 000 measurements). The Orbiting Carbon Observatory-2 (OCO-2) allows measurements of CO₂ content with a high accuracy (0.25-0.5%) (for data with a quality flag “0”), a high horizontal resolution (1.29´ 2.25 км²), and a spatial coverage along paths of ~ 10 km. That makes it possible to analyze the spatial and temporal variations in CO₂ column-averaged dry-air mole fractions (XCO₂). XCO₂ OCO-2 data with quality flag “1” has lower measurement accuracy, but the number of such measurements is 5-10 times greater than that with quality flag “0”. XCO₂ satellite measurements with quality flag “0” in the vicinity of Moscow, Saint Petersburg, Yekaterinburg, Magnitogorsk, and Norilsk (circles with a radius of 100 km from the city centers) have been analyzed. Compariso