The research objective is comparison of psychoe motional state of patients suffering from disseminated sclerosis that were taking Enterococcus faecium L-3 and patients and that were not taking it. Research materials and methods. For evaluation of psychoe motional state of patients suffering from disse minated sclerosis two groups were created (control group and experimental group), each of the m amounted to 15 persons having definite diagnosis dissminated sclerosis. Standard questionnaires were used («Dominant condition» and «Actual condition» by L.V. Kulikov, questionnaire «Health,activ-ity,mood»,scale of situational (reactive) state anxiety by Ch.D. Spilberger and Yu.L. Khanin,and technique of differential diagnostics of depressive states by V. Zung). Results. After a course of probiotics intake indices at patients of experimental group (р<0.05) have been definitely improved in accordance withscales of the «Dominating state» questionnaire: «Relaxedness - potential stress», «Evenness - psychic tension», «Stability - instability of emotional background», «Satisfaction - dissatisfaction withlife in general» and in accordance withthe scale „Evenness - psychictension“ of the „Actual state“ questionnaire. Opinion. Obtained results bear evidence that the course intake of Enterococcus faecium L-3 has positive influence on psychoe motional state of patients having the diagnosis disse minated sclerosis.