The influence of the mouse female pheromone 2,5-dimethylpyrazine was studied on significant reproductive characteristics in C57BL/6 males. With this purpose the frequency of pheromonally induced sperm head abnormalities and dominant lethal frequency was analyzed. It is shown, that the level of different sperm head abnormalities increases significantly after exposure with the pheromones. Simultaneously with it the frequency of dominant lethals elevates significantly in the progeny of the treated males. Connection of the revealed effects with the destabilizing influence of the pheromone on the genome of dividing germ and somatic cells at laboratory mice is discussed