TY - JOUR

T1 - НЕВРОЛОГИЧЕСКИЕ ОСЛОЖНЕНИЯ И ПОСЛЕДСТВИЯ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ COVID-19 У ПАЦИЕНТОВ ПОЖИЛОГО И СТАРЧЕСКОГО ВОЗРАСТА (обзор литературы).

AU - Флуд, Виктор Васильевич

AU - Щербук, Юрий Александрович

AU - Щербук, Александр Юрьевич

AU - Леонов, Валентин Игоревич

AU - Аль-Сахли, Усама Абдулвахаб Мохаммед

PY - 2022/5/24

Y1 - 2022/5/24

N2 - Based on the available publications, the article systematizes information about some forms of lesions of the central nervous system (CNS), their pathogenesis, and clinical manifestations in COVID-19. Risk factors, developmental mechanisms, diagnostic approach, age characteristics of patients with neurological complications of COVID-19 are discussed. The specific mechanisms of the neuroinvasiveness and neurovirulence of the SARS-CoV-2 virus, regardless of the age of patients and the presence of risk factors, lead to systemic damage to the endothelium of small-caliber vessels, generalized thrombovasculitis, and an increased risk of ischemic and hemorrhagic strokes. At the same time, the most vulnerable category is elderly and senile patients with cardiovascular and metabolic disorders (arterial hypertension, obesity, diabetes mellitus), which sharply worsen treatment outcomes. The clinical experience accumulated during the COVID-19 pandemic indicates the development of the following most frequent post-covid neurological complications and consequences in mainly elderly and senile patients: cranial mononeuropathies, chemosensory dysfunction, encephalopathy, insomnia, stroke, acute meningoencephalitis, acute disseminated encephalomyelitis syndrome acute polyneuropathy Guillain-Barré, transverse myelitis. The benefits of vaccination against COVID-19 far outweigh the risks of possible post-vaccination neurological complications and consequences, especially in elderly and senile patients.

AB - Based on the available publications, the article systematizes information about some forms of lesions of the central nervous system (CNS), their pathogenesis, and clinical manifestations in COVID-19. Risk factors, developmental mechanisms, diagnostic approach, age characteristics of patients with neurological complications of COVID-19 are discussed. The specific mechanisms of the neuroinvasiveness and neurovirulence of the SARS-CoV-2 virus, regardless of the age of patients and the presence of risk factors, lead to systemic damage to the endothelium of small-caliber vessels, generalized thrombovasculitis, and an increased risk of ischemic and hemorrhagic strokes. At the same time, the most vulnerable category is elderly and senile patients with cardiovascular and metabolic disorders (arterial hypertension, obesity, diabetes mellitus), which sharply worsen treatment outcomes. The clinical experience accumulated during the COVID-19 pandemic indicates the development of the following most frequent post-covid neurological complications and consequences in mainly elderly and senile patients: cranial mononeuropathies, chemosensory dysfunction, encephalopathy, insomnia, stroke, acute meningoencephalitis, acute disseminated encephalomyelitis syndrome acute polyneuropathy Guillain-Barré, transverse myelitis. The benefits of vaccination against COVID-19 far outweigh the risks of possible post-vaccination neurological complications and consequences, especially in elderly and senile patients.

KW - COVID-19 associated neurological complications and consequences

KW - elderly and senile patients

KW - novel coronavirus infection COVID-19

UR - https://www.mendeley.com/catalogue/8f04d7fc-6a6f-32dd-a079-1f587ae7d6fd/

UR - http://www.scopus.com/inward/record.url?scp=85132283941&partnerID=8YFLogxK

U2 - 10.34922/ae.2022.35.2.007

DO - 10.34922/ae.2022.35.2.007

M3 - статья

C2 - 35727930

AN - SCOPUS:85132283941

VL - 35

SP - 231

EP - 242

JO - УСПЕХИ ГЕРОНТОЛОГИИ

JF - УСПЕХИ ГЕРОНТОЛОГИИ

SN - 1561-9125

IS - 2

ER -