A historical and biographical sketch devoted to the 200th anniversary of the genius of Pathophysiology and the reformer of medicine Charles-Edouard Brown-Séquard (1817-1894), a prominent pathophysiological experimentalist, innovative prophetic theoretician, an outstanding neuropathologist, the first descriptor of the syndrome bearing his name, the forerunner of Endocrinology, discoverer of vasomotor nerves and spinal shock, and the initiator of organotherapy. His life and works are reviewed in context of epoch, in links to his contemporaries, outstanding figures of French and British science and culture and on background of paralleling historical events (3 figs., bibliography: 19 refs).