A clinical-population study was conducted to identify patterns in the dynamics of incidence, mortality, and patient accounting for liver cancer in Russia, as well as the specifics of changes in the structure of affected individuals by detailed localization and age. Over an 11-year period, the incidence of liver cancer in Russia increased by 24.4%, while mortality rose by 9.6%. Special attention was paid to the nature of changes in age-specific incidence and mortality rates for the population of Russia with liver cancer. The aim of the study was to investigate the dynamics of key parameters of incidence, mortality, and the quality of primary patient accounting for liver cancer at the population level in Russia and the Northwestern Federal District of the Russian Federation. The study results confirmed the severity of the problem of this pathology and the challenges associated with the timely detection and provision of adequate care to patients with liver cancer. In some territories, the mortality rate from liver cancer exceeded the number of newly diagnosed patients by 2–3 times. The impact of the coronavirus infection pandemic on the quality of registration of liver cancer patients was also assessed. The study also presented modern possibilities for early diagnosis and treatment of patients with liver cancer.