With the use of the voltage-clamp technique the involvement of the cyclooxygenase and lipoxygenase oxidation pathways of
arachidonic acid metabolism in the effect of immunomodulator glutoxim on Na+
transport in frog skin was investigated. It was
shown that three structurally different inhibitors of cyclooxygenases indomethacin, meloxicam, acetylsalicylic acid (aspirin), the
lipoxygenase inhibitor caffeic acid, and the 12-lipoxygenase inhibitor baicalein decrease the stimulatory effect of glutoxim on
Na+
transport in frog skin. The results suggest that the cyclooxygenase and lipoxygenase oxidation pathways of arachidonic acid
play an important role in glutoxim regulation of Na+
transport in frog skin.