BACKGROUND. Chronic kidney disease affects almost all organ systems. Respiratory lesions in these patients are often underestimated in clinical practice. THE AIM. Diagnosis and clinical evaluation of the respiratory system in patients with high-flux hemodialysis to optimize the treatment of patients with chronic kidney disease. PATIENTS AND METHODS. There were 60 patients examined. Two groups were considered: the main group - patients with chronic glomerulonephritis (in 17 patients, the diagnosis was confirmed morphologically) with stage 5 chronic kidney disease (CKD), receiving hemodialysis therapy (n = 30), and the comparison group - patients not receiving dialysis (n = 30). Experience of smoking, results of clinical, biochemical blood tests and respiratory tests - vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC and maximum voluntary ventilation (MVV) were studied in all patients. RESULTS. The mean body mass index (BMI) in the main group of patients wa