This article is focused on evaluation of role of psychocardiac comorbidity index in risk stratification of patients presenting with NSTE-ACS. A retrospective analysis of 367 health records of patients presenting with NSTE-ACS has shown that that both Index of psychocardiac comorbidity (AUC 0,668 ± 0,026, p < 0,001) and troponin I at admission (TnI0) are independent predictors of ruled out NSTE-ACS. Anxiety measured by Hospital anxiety and depression scale was associated with higher risk of myocardial infarction (NSTEMI) in patients with verified NSTE-ACS (mean score 9,83 ± 3,61 vs. 7,08 ± 3,96 for NSTEMI vs. unstable angina, p = 0,035). No cases of NSTEMI was deteсted in subgroup of TnI0 < 2,0 pg/ml. The results suggest that clinical and psychological characteristics of patients presenting with NSTE-ACS might be used as an additional instrument of risk evaluation in NSTE-ACS subpopulation.