Over the past few years, the consumption of drugs derived from medicines and drugs freely sold in the pharmacy network has increased in the country. «Pharmacy» drug addiction has become a real disaster for the country, rapidly spreading to all regions and subjects of the Russian Federation. Pharmaceutical organizations, as subjects of the pharmaceutical market, are obliged to ensure the availability of medicines, including those containing narcotic drugs, psychotropic substances and their precursors for medical purposes, and at the same time are obliged to provide conditions to prevent the possibility of illegal trafficking of these funds. The article analyzes the state of issues and problems in the sphere of circulation of medicines and their non-medical consumption, identifies problematic aspects of law enforcement, identifies the main directions of improving prevention and organizational work in this direction.