Изменения эндотелийзависимого и миогенного механизмов действия серотонина в лимфатических сосудах брыжейки крыс при экспериментальном перитоните. / Егорова, А.А.; Авраменко, Екатерина Александровна.
In: Фундаментальная и клиническая медицина, Vol. 5, No. 3, 2020, p. 35-41.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Изменения эндотелийзависимого и миогенного механизмов действия серотонина в лимфатических сосудах брыжейки крыс при экспериментальном перитоните
AU - Егорова, А.А.
AU - Авраменко, Екатерина Александровна
PY - 2020
Y1 - 2020
N2 - Aim. To compare the reactions to 5-hydroxytryptamine (5-HT, serotonin) in the mesenteric lymphangions upon endothelial denudation and during experimental faecal peritonitis as compared with the control lymphangions. Materials and Methods. Experiments were performed on the intestinal lymph trunk lymphangions of rats using a pressure myograph system. We examined the changes in contraction frequency and amplitude as well as tonic reactions upon the addition of 5-HT (10-8-10-4 M). Experimental peritonitis was caused by an intraperitoneal injection of feces. Results. Faecal peritonitis reduced contraction frequency and amplitude in mesenteric lymphangions. 5-HT increased contraction amplitude only at low concentration (10-8 M) and did not alter the tonic reactions. Upon endothelial denudation, serotonin inhibited contraction frequency and amplitude in the lymphangions. As 5-HT stimulates motility through 5-НТ2 receptors and α2-adrenoceptors on endothelial cells, faecal peritonitis abates the sensitivity of such receptors to 5-HT. Conclusion. In experimental faecal peritonitis, alterations in lymphatic vessels are reminiscent of those in blood vessels. Endothelial dysfunction disturbs the response of lymphatic vessels to 5-HT.
AB - Aim. To compare the reactions to 5-hydroxytryptamine (5-HT, serotonin) in the mesenteric lymphangions upon endothelial denudation and during experimental faecal peritonitis as compared with the control lymphangions. Materials and Methods. Experiments were performed on the intestinal lymph trunk lymphangions of rats using a pressure myograph system. We examined the changes in contraction frequency and amplitude as well as tonic reactions upon the addition of 5-HT (10-8-10-4 M). Experimental peritonitis was caused by an intraperitoneal injection of feces. Results. Faecal peritonitis reduced contraction frequency and amplitude in mesenteric lymphangions. 5-HT increased contraction amplitude only at low concentration (10-8 M) and did not alter the tonic reactions. Upon endothelial denudation, serotonin inhibited contraction frequency and amplitude in the lymphangions. As 5-HT stimulates motility through 5-НТ2 receptors and α2-adrenoceptors on endothelial cells, faecal peritonitis abates the sensitivity of such receptors to 5-HT. Conclusion. In experimental faecal peritonitis, alterations in lymphatic vessels are reminiscent of those in blood vessels. Endothelial dysfunction disturbs the response of lymphatic vessels to 5-HT.
UR - https://www.mendeley.com/catalogue/902ec7c9-d36b-3104-bc91-70ff944c48fd/
U2 - 10.23946/2500-0764-2020-5-3-35-41
DO - 10.23946/2500-0764-2020-5-3-35-41
M3 - статья
VL - 5
SP - 35
EP - 41
JO - Фундаментальная и клиническая медицина
JF - Фундаментальная и клиническая медицина
SN - 2500-0764
IS - 3
ER -
ID: 71549139