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Эффективность фиксированной комбинации розувастатина и эзетимиба при гетерозиготной семейной гиперхолестеринемии по данным регистра РЕНЕССАНС. / Alekseeva, I. A.; Chubykina, U. V.; Ezhov, M. V.; Tyurina, A. V.; Kolmakova, T. E.; Tmoyan, N. A.; Sokolov, A. A.; Rozhkova, T. A.; Kurochkina, N. S.; Sergienko, I. V.; Avdeeva, I. V.; Oleynikov, V. E.; Alieva, A. S.; Androsyuk, N. G.; Kiselevа, M. A.; Grigorieva, Yu. G.; Asekritova, A. S.; Kylbanova, E. S.; Pavlova, A. V.; Ershova, A. I.; Meshkov, A. N.; Mikhailina, V. I.; Blokhina, A. V.; Limonova, A. S.; Kopylova, O. V.; Vorobyev, A. S.; Astrakhantseva, I. D.; Vorobyeva, Yu. A.; Ermakova, Yu. A.; Sadykova, D. I.; Slastnikova, E. S.; Galimovа, L. F.; Shaposhnik, I. I.; Genkel, V. V.; Egorova, A. V.; Mukha, N. V.; Vasilenko, P. V.; Zaitsev, D. N.; Kim, Z. F.; Zafiraki, V. K.; Zykov, M. V.; Korneva, V. A.; Kuznetsova, T. Yu.; Malyshenko, Yu. A.; Petelina, T. I.; Mikova, E. V.; Namitokov, A. M.; Kosmacheva, E. D.; Pshenichnikova, I. I.; Konstantinov, V. O.; Bednova, S. E.; Voevoda, M. I.; Timoshenko, O. V.; Ragino, Yu. I.; Filippov, A. E.; Tuktarov, A. M.; Gurevich, V. S.; Muzalevskaya, M. V.; Urazgildeevа, S. A.; Khokhlov, R. A.; Yarkovaya, S. V.; Shutemova, E. A.; Kudelkina, E. V.; Bizyaeva, N. N.
In:
Рациональная фармакотерапия в кардиологии, Vol. 21, No. 3, 22.08.2025, p. 244-256.
Research output: Contribution to journal › Article › peer-review
Harvard
Alekseeva, IA, Chubykina, UV, Ezhov, MV, Tyurina, AV, Kolmakova, TE, Tmoyan, NA, Sokolov, AA, Rozhkova, TA, Kurochkina, NS, Sergienko, IV, Avdeeva, IV, Oleynikov, VE, Alieva, AS, Androsyuk, NG, Kiselevа, MA, Grigorieva, YG, Asekritova, AS, Kylbanova, ES
, Pavlova, AV, Ershova, AI, Meshkov, AN, Mikhailina, VI, Blokhina, AV, Limonova, AS, Kopylova, OV, Vorobyev, AS, Astrakhantseva, ID, Vorobyeva, YA, Ermakova, YA, Sadykova, DI, Slastnikova, ES, Galimovа, LF, Shaposhnik, II, Genkel, VV, Egorova, AV, Mukha, NV, Vasilenko, PV, Zaitsev, DN, Kim, ZF, Zafiraki, VK, Zykov, MV, Korneva, VA, Kuznetsova, TY, Malyshenko, YA, Petelina, TI, Mikova, EV, Namitokov, AM, Kosmacheva, ED, Pshenichnikova, II, Konstantinov, VO, Bednova, SE, Voevoda, MI, Timoshenko, OV, Ragino, YI, Filippov, AE, Tuktarov, AM
, Gurevich, VS, Muzalevskaya, MV, Urazgildeevа, SA, Khokhlov, RA, Yarkovaya, SV, Shutemova, EA, Kudelkina, EV & Bizyaeva, NN 2025, '
Эффективность фиксированной комбинации розувастатина и эзетимиба при гетерозиготной семейной гиперхолестеринемии по данным регистра РЕНЕССАНС',
Рациональная фармакотерапия в кардиологии, vol. 21, no. 3, pp. 244-256.
https://doi.org/10.20996/1819-6446-2025-3205,
https://doi.org/10.20996/1819-6446-2025-3205APA
Alekseeva, I. A., Chubykina, U. V., Ezhov, M. V., Tyurina, A. V., Kolmakova, T. E., Tmoyan, N. A., Sokolov, A. A., Rozhkova, T. A., Kurochkina, N. S., Sergienko, I. V., Avdeeva, I. V., Oleynikov, V. E., Alieva, A. S., Androsyuk, N. G., Kiselevа, M. A., Grigorieva, Y. G., Asekritova, A. S., Kylbanova, E. S.
, Pavlova, A. V., ... Bizyaeva, N. N. (2025).
Эффективность фиксированной комбинации розувастатина и эзетимиба при гетерозиготной семейной гиперхолестеринемии по данным регистра РЕНЕССАНС.
Рациональная фармакотерапия в кардиологии,
21(3), 244-256.
https://doi.org/10.20996/1819-6446-2025-3205,
https://doi.org/10.20996/1819-6446-2025-3205Vancouver
Author
Alekseeva, I. A. ; Chubykina, U. V. ; Ezhov, M. V. ; Tyurina, A. V. ; Kolmakova, T. E. ; Tmoyan, N. A. ; Sokolov, A. A. ; Rozhkova, T. A. ; Kurochkina, N. S. ; Sergienko, I. V. ; Avdeeva, I. V. ; Oleynikov, V. E. ; Alieva, A. S. ; Androsyuk, N. G. ; Kiselevа, M. A. ; Grigorieva, Yu. G. ; Asekritova, A. S. ; Kylbanova, E. S.
; Pavlova, A. V. ; Ershova, A. I. ; Meshkov, A. N. ; Mikhailina, V. I. ; Blokhina, A. V. ; Limonova, A. S. ; Kopylova, O. V. ; Vorobyev, A. S. ; Astrakhantseva, I. D. ; Vorobyeva, Yu. A. ; Ermakova, Yu. A. ; Sadykova, D. I. ; Slastnikova, E. S. ; Galimovа, L. F. ; Shaposhnik, I. I. ; Genkel, V. V. ; Egorova, A. V. ; Mukha, N. V. ; Vasilenko, P. V. ; Zaitsev, D. N. ; Kim, Z. F. ; Zafiraki, V. K. ; Zykov, M. V. ; Korneva, V. A. ; Kuznetsova, T. Yu. ; Malyshenko, Yu. A. ; Petelina, T. I. ; Mikova, E. V. ; Namitokov, A. M. ; Kosmacheva, E. D. ; Pshenichnikova, I. I. ; Konstantinov, V. O. ; Bednova, S. E. ; Voevoda, M. I. ; Timoshenko, O. V. ; Ragino, Yu. I. ; Filippov, A. E. ; Tuktarov, A. M.
; Gurevich, V. S. ; Muzalevskaya, M. V. ; Urazgildeevа, S. A. ; Khokhlov, R. A. ; Yarkovaya, S. V. ; Shutemova, E. A. ; Kudelkina, E. V. ; Bizyaeva, N. N. /
Эффективность фиксированной комбинации розувастатина и эзетимиба при гетерозиготной семейной гиперхолестеринемии по данным регистра РЕНЕССАНС. In:
Рациональная фармакотерапия в кардиологии. 2025 ; Vol. 21, No. 3. pp. 244-256.
BibTeX
@article{c23281de8de84d0cada385def7bad18d,
title = "Эффективность фиксированной комбинации розувастатина и эзетимиба при гетерозиготной семейной гиперхолестеринемии по данным регистра РЕНЕССАНС",
abstract = "Aim. To study the adequacy and effectiveness of lipid-lowering therapy (LLT) prescribed to patients with heterozygous familial hypercholesterolemia (HeFH), including fixed-dose combinations (FDC) of rosuvastatin with ezetimibe, as well as the frequency of achieving target low-density lipoprotein cholesterol (LDL-C) levels. Material and methods. The clinical and demographic data of 3151 patients with HeFH at high or very high cardiovascular risk from the RENAISSANCE registry were retrospectively analysed. Among the 1612 individuals receiving LLT, 477 patients were treated with a combination of rosuvastatin at various doses and ezetimibe 10 mg daily, either as a free combination or as a FDC. Results. The median age of the patients was 46.0 [32.0; 57.0] years. The median LDL-C level was 6.4 [5.3; 7.8] mmol/L. Although LLT was recommended to all participants, approximately half (49%, n=1539) were not receiving treatment. Among the 1612 patients on LLT, 44% (n=703) received statin mono therapy, and 43% (n=697) were treated with a combination of statins and ezetimibe. Of the 477 patients taking rosuvastatin with ezetimibe, the majority were active adults of working age (35-64 years): 335 (80%) vs 86 (20%), p",
keywords = "ezetimibe, fixed-dose combination, heterozygous familial hypercholesterolemia, low density lipoprotein cholesterol, registry, rosuvastatin",
author = "Alekseeva, {I. A.} and Chubykina, {U. V.} and Ezhov, {M. V.} and Tyurina, {A. V.} and Kolmakova, {T. E.} and Tmoyan, {N. A.} and Sokolov, {A. A.} and Rozhkova, {T. A.} and Kurochkina, {N. S.} and Sergienko, {I. V.} and Avdeeva, {I. V.} and Oleynikov, {V. E.} and Alieva, {A. S.} and Androsyuk, {N. G.} and Kiselevа, {M. A.} and Grigorieva, {Yu. G.} and Asekritova, {A. S.} and Kylbanova, {E. S.} and Pavlova, {A. V.} and Ershova, {A. I.} and Meshkov, {A. N.} and Mikhailina, {V. I.} and Blokhina, {A. V.} and Limonova, {A. S.} and Kopylova, {O. V.} and Vorobyev, {A. S.} and Astrakhantseva, {I. D.} and Vorobyeva, {Yu. A.} and Ermakova, {Yu. A.} and Sadykova, {D. I.} and Slastnikova, {E. S.} and Galimovа, {L. F.} and Shaposhnik, {I. I.} and Genkel, {V. V.} and Egorova, {A. V.} and Mukha, {N. V.} and Vasilenko, {P. V.} and Zaitsev, {D. N.} and Kim, {Z. F.} and Zafiraki, {V. K.} and Zykov, {M. V.} and Korneva, {V. A.} and Kuznetsova, {T. Yu.} and Malyshenko, {Yu. A.} and Petelina, {T. I.} and Mikova, {E. V.} and Namitokov, {A. M.} and Kosmacheva, {E. D.} and Pshenichnikova, {I. I.} and Konstantinov, {V. O.} and Bednova, {S. E.} and Voevoda, {M. I.} and Timoshenko, {O. V.} and Ragino, {Yu. I.} and Filippov, {A. E.} and Tuktarov, {A. M.} and Gurevich, {V. S.} and Muzalevskaya, {M. V.} and Urazgildeevа, {S. A.} and Khokhlov, {R. A.} and Yarkovaya, {S. V.} and Shutemova, {E. A.} and Kudelkina, {E. V.} and Bizyaeva, {N. N.}",
year = "2025",
month = aug,
day = "22",
doi = "10.20996/1819-6446-2025-3205",
language = "русский",
volume = "21",
pages = "244--256",
journal = "Rational Pharmacotherapy in Cardiology",
issn = "1819-6446",
publisher = "Столичная издательская компания",
number = "3",
}
RIS
TY - JOUR
T1 - Эффективность фиксированной комбинации розувастатина и эзетимиба при гетерозиготной семейной гиперхолестеринемии по данным регистра РЕНЕССАНС
AU - Alekseeva, I. A.
AU - Chubykina, U. V.
AU - Ezhov, M. V.
AU - Tyurina, A. V.
AU - Kolmakova, T. E.
AU - Tmoyan, N. A.
AU - Sokolov, A. A.
AU - Rozhkova, T. A.
AU - Kurochkina, N. S.
AU - Sergienko, I. V.
AU - Avdeeva, I. V.
AU - Oleynikov, V. E.
AU - Alieva, A. S.
AU - Androsyuk, N. G.
AU - Kiselevа, M. A.
AU - Grigorieva, Yu. G.
AU - Asekritova, A. S.
AU - Kylbanova, E. S.
AU - Pavlova, A. V.
AU - Ershova, A. I.
AU - Meshkov, A. N.
AU - Mikhailina, V. I.
AU - Blokhina, A. V.
AU - Limonova, A. S.
AU - Kopylova, O. V.
AU - Vorobyev, A. S.
AU - Astrakhantseva, I. D.
AU - Vorobyeva, Yu. A.
AU - Ermakova, Yu. A.
AU - Sadykova, D. I.
AU - Slastnikova, E. S.
AU - Galimovа, L. F.
AU - Shaposhnik, I. I.
AU - Genkel, V. V.
AU - Egorova, A. V.
AU - Mukha, N. V.
AU - Vasilenko, P. V.
AU - Zaitsev, D. N.
AU - Kim, Z. F.
AU - Zafiraki, V. K.
AU - Zykov, M. V.
AU - Korneva, V. A.
AU - Kuznetsova, T. Yu.
AU - Malyshenko, Yu. A.
AU - Petelina, T. I.
AU - Mikova, E. V.
AU - Namitokov, A. M.
AU - Kosmacheva, E. D.
AU - Pshenichnikova, I. I.
AU - Konstantinov, V. O.
AU - Bednova, S. E.
AU - Voevoda, M. I.
AU - Timoshenko, O. V.
AU - Ragino, Yu. I.
AU - Filippov, A. E.
AU - Tuktarov, A. M.
AU - Gurevich, V. S.
AU - Muzalevskaya, M. V.
AU - Urazgildeevа, S. A.
AU - Khokhlov, R. A.
AU - Yarkovaya, S. V.
AU - Shutemova, E. A.
AU - Kudelkina, E. V.
AU - Bizyaeva, N. N.
PY - 2025/8/22
Y1 - 2025/8/22
N2 - Aim. To study the adequacy and effectiveness of lipid-lowering therapy (LLT) prescribed to patients with heterozygous familial hypercholesterolemia (HeFH), including fixed-dose combinations (FDC) of rosuvastatin with ezetimibe, as well as the frequency of achieving target low-density lipoprotein cholesterol (LDL-C) levels. Material and methods. The clinical and demographic data of 3151 patients with HeFH at high or very high cardiovascular risk from the RENAISSANCE registry were retrospectively analysed. Among the 1612 individuals receiving LLT, 477 patients were treated with a combination of rosuvastatin at various doses and ezetimibe 10 mg daily, either as a free combination or as a FDC. Results. The median age of the patients was 46.0 [32.0; 57.0] years. The median LDL-C level was 6.4 [5.3; 7.8] mmol/L. Although LLT was recommended to all participants, approximately half (49%, n=1539) were not receiving treatment. Among the 1612 patients on LLT, 44% (n=703) received statin mono therapy, and 43% (n=697) were treated with a combination of statins and ezetimibe. Of the 477 patients taking rosuvastatin with ezetimibe, the majority were active adults of working age (35-64 years): 335 (80%) vs 86 (20%), p
AB - Aim. To study the adequacy and effectiveness of lipid-lowering therapy (LLT) prescribed to patients with heterozygous familial hypercholesterolemia (HeFH), including fixed-dose combinations (FDC) of rosuvastatin with ezetimibe, as well as the frequency of achieving target low-density lipoprotein cholesterol (LDL-C) levels. Material and methods. The clinical and demographic data of 3151 patients with HeFH at high or very high cardiovascular risk from the RENAISSANCE registry were retrospectively analysed. Among the 1612 individuals receiving LLT, 477 patients were treated with a combination of rosuvastatin at various doses and ezetimibe 10 mg daily, either as a free combination or as a FDC. Results. The median age of the patients was 46.0 [32.0; 57.0] years. The median LDL-C level was 6.4 [5.3; 7.8] mmol/L. Although LLT was recommended to all participants, approximately half (49%, n=1539) were not receiving treatment. Among the 1612 patients on LLT, 44% (n=703) received statin mono therapy, and 43% (n=697) were treated with a combination of statins and ezetimibe. Of the 477 patients taking rosuvastatin with ezetimibe, the majority were active adults of working age (35-64 years): 335 (80%) vs 86 (20%), p
KW - ezetimibe
KW - fixed-dose combination
KW - heterozygous familial hypercholesterolemia
KW - low density lipoprotein cholesterol
KW - registry
KW - rosuvastatin
UR - https://www.mendeley.com/catalogue/c4011e9f-9389-309e-894e-2dc45f6476ff/
U2 - 10.20996/1819-6446-2025-3205
DO - 10.20996/1819-6446-2025-3205
M3 - статья
VL - 21
SP - 244
EP - 256
JO - Rational Pharmacotherapy in Cardiology
JF - Rational Pharmacotherapy in Cardiology
SN - 1819-6446
IS - 3
ER -
