TY - JOUR

T1 - Динамика изменения показателей местного иммунитета рта у пациентов молодого возраста в период ортодонтического лечения

AU - Soldatov, V.S.

AU - Malyshev, M.E.

AU - Soldatova, L.N.

AU - Iordanishvili, A.K.

N1 - Export Date: 05 February 2026; Cited By: 0; Correspondence Address: V.S. Soldatov; Alfa-Dent Clinics, St. Petersburg, Russian Federation; email: solves5@yandex.ru

PY - 2025

Y1 - 2025

N2 - The development of simple and accessible tools for improvement of dental health over active period of orthodontic treatment with fixed arch appliances (bracket system) is a pressing issue in clinical dentistry. The aim of this study was to investigate the effects of regular usage of oral care products on mucosal immunity in young people undergoing active period of orthodontic treatment using fixed arch appliances. The study involved 39 persons (17 men, 22 women), aged 18 to 28 years, suffering from dentoalveolar anomalies without concomitant somatic pathology. The patients were divided in 2 groups: the comparison group (1) and the main group (2). Patients in Group 1 (16 subjects, 7 men and 9 women), used their usual personal hygiene products throughout the study. Patients in Group 2, (23 persons, 10 men and 13 women) were recommended to use a new domestic low-abrasive toothpaste for sensitive teeth with a triple mechanism of tooth and gum protection, containing copper chlorophyllin at a concentration sufficient to inhibit periodontopathogenic bacteria, calcium glycerophosphate, calcium hydroxyapatite suspension, potassium chloride, silicon dioxide, magnesium chloride and xylitol (R.O.C.S. PRO SENSITIVE). The control age-matched group consisted of 15 people (6 men, 9 women) without dental anomalies and not requiring orthodontic treatment. The biological material was the patients’ oral fluid. The salivary contents of secretory immunoglobulin A, as well as some pro-inflammatory and anti-inflammatory cytokines were determined using the enzyme immunoassay method. The study has revealed unfavorable dynamics in terms of secretory immunoglobulin A, concentrations of pro- and anti-inflammatory cytokines in salivary fluid among young patients using braces at the active stage of orthodontic treatment. The usage of recommended dental and oral care products allowed us to optimize mucosal immunity and normalize the cytokine balance within a month, as well as to maintain it for a long time in complex cases of orthodontic treatment. To maintain dental health during the active period of orthodontic treatment with braces, an algorithm of individual oral care should be kept, by usage of oral hygiene products containing plant-based components with antimicrobial action. © Soldatov V.S. et al., 2025.

AB - The development of simple and accessible tools for improvement of dental health over active period of orthodontic treatment with fixed arch appliances (bracket system) is a pressing issue in clinical dentistry. The aim of this study was to investigate the effects of regular usage of oral care products on mucosal immunity in young people undergoing active period of orthodontic treatment using fixed arch appliances. The study involved 39 persons (17 men, 22 women), aged 18 to 28 years, suffering from dentoalveolar anomalies without concomitant somatic pathology. The patients were divided in 2 groups: the comparison group (1) and the main group (2). Patients in Group 1 (16 subjects, 7 men and 9 women), used their usual personal hygiene products throughout the study. Patients in Group 2, (23 persons, 10 men and 13 women) were recommended to use a new domestic low-abrasive toothpaste for sensitive teeth with a triple mechanism of tooth and gum protection, containing copper chlorophyllin at a concentration sufficient to inhibit periodontopathogenic bacteria, calcium glycerophosphate, calcium hydroxyapatite suspension, potassium chloride, silicon dioxide, magnesium chloride and xylitol (R.O.C.S. PRO SENSITIVE). The control age-matched group consisted of 15 people (6 men, 9 women) without dental anomalies and not requiring orthodontic treatment. The biological material was the patients’ oral fluid. The salivary contents of secretory immunoglobulin A, as well as some pro-inflammatory and anti-inflammatory cytokines were determined using the enzyme immunoassay method. The study has revealed unfavorable dynamics in terms of secretory immunoglobulin A, concentrations of pro- and anti-inflammatory cytokines in salivary fluid among young patients using braces at the active stage of orthodontic treatment. The usage of recommended dental and oral care products allowed us to optimize mucosal immunity and normalize the cytokine balance within a month, as well as to maintain it for a long time in complex cases of orthodontic treatment. To maintain dental health during the active period of orthodontic treatment with braces, an algorithm of individual oral care should be kept, by usage of oral hygiene products containing plant-based components with antimicrobial action. © Soldatov V.S. et al., 2025.

KW - cytokines

KW - dental anomalies

KW - hygiene products

KW - mucosal immunity

KW - orthodontic treatment

KW - secretory immunoglobulin

KW - biomaterial

KW - chlorophyll

KW - copper

KW - glycerophosphate calcium

KW - hydroxyapatite

KW - magnesium chloride

KW - potassium chloride

KW - silicon dioxide

KW - toothpaste

KW - xylitol

KW - adult

KW - antiinflammatory activity

KW - antimicrobial activity

KW - Article

KW - clinical article

KW - comparative study

KW - concentration process

KW - controlled study

KW - dental health

KW - dentin hypersensitivity

KW - dentoalveolar anomaly

KW - enzyme immunoassay

KW - female

KW - fluid intake

KW - histopathology

KW - human

KW - immune response

KW - male

KW - molecular dynamics

KW - mouth cavity

KW - mouth hygiene

KW - orthodontic procedure

KW - personal hygiene

KW - saliva analysis

KW - tooth

KW - tooth malformation

U2 - 10.15789/1563-0625-DOC-3183

DO - 10.15789/1563-0625-DOC-3183

M3 - статья

VL - 27

SP - 553

EP - 560

JO - Medical Immunology (Russia)

JF - Medical Immunology (Russia)

SN - 1563-0625

IS - 3

ER -