The paper deals with methodological issues related to the link between the processes of forming the internal picture of the disease and coping behavior in the dynamics of the subjective and objective factors of the psychosocial functioning of the personality. From our point of view, there are significant stages, implying the association of the components of the internal picture of the disease, as well as the personal meaning of health and coping behavior. The variants of their interdependence in the structure of the integral adaptation process are considered, which, in turn, determines the patient’s essential understanding and assessment of the quality of life (QOL) in the actual life situation.