Summary The aim of the study was to study the trends in the prevalence of respiratory tuberculosis with bacterial excretion with multidrug resistance of mycobacterium tuberculosis (MDR-TB), including in combination with HIV infection, in the North-West Federal District of Russia. Materials and methods. The prevalence of MDR-TB was studied in 2005-2017 in the North-West region in comparison with other federal districts of the Russian Federation. In 9 subjects of the North-West region, the dynamics of the number of patients, who have isolated mycobacterium tuberculosis with the presence and absence of HIV infection was studied over 5 years. Results. The prevalence of tuberculosis with MDR in the Northwestern Federal District stabilized in 2007-2012, and by 2017 it decreased by 31.6% to 14.5 per 100.000. The share of MDR-TB patients with bacterial excretion continues to grow: in the Russian Federation up to 59.0%, in the North-West Federal District up to 60.8% in 2017. A special feature of the North-West Feder
