This article will present the result of an analysis of the geopolitical and geo-economic interests of China, Russia and the United States in the Central Asian region. Central Asia is a field of world power collision because of this region is characterized by an advantageous geostrategic position, communication and energy opportunities, and a significant stock of natural resources. The strategy implemented by China is aimed to cooperate in the development and transportation of hydrocarbon raw materials, the development of the region’s energy potential, the development of hydro resources, the development of transport communications, and industrial facilities. China takes first position of investments and loans in the economy of the republics. There is a cooperation in the fight against terrorism, extremism, drug crime. The United States is pursuing its own national interests in Central Asia in the military-strategic sphere, as well as by investing in the development of the oil and gas industry. The weakening of Russia and China influence in the region also belongs to the national interests of the United States. The realization of Russian’s geopolitical interests is connected with ensuring national security by protecting state borders, combating terrorism and religious extremism, drug crime. Geo-economic interests are associated with the development and transportation of natural resources (hydrocarbon raw materials), cooperation in the energy and transport and transit sectors. In addition, in this article will be analyze a number of geopolitical models that characterize Russian policy in Central Asia.