Experimental evaluation of the effectiveness of wound coatings based on bacterial cellulose impregnated with fucoidan solution for deep skin burns is presented. Forty rats were involved in the experiments. Application of wound coatings based on bacterial cellulose with 2% fucoidan solution with a thickness of 0,5 to 1 mm and 1 to 2 mm was found to show a clear tendency to accelerate healing of wound defects by 54 and 47%, respectively (p<0,2), compared to the control group, on the 14th day. The use of the same coatings without impregnation with fucoidan was less effective and led to the reduction of wound defect only by 39% (p<0,2) compared to the control, by the end of the second week. Histological examination of wound biopsies revealed a significant acceleration of the formation and maturation of connective tissue due to intensive angiogenesis and increased proliferative activity of fibroblastic cells. It was shown that after 14 days the designed wound coatings based on bacterial cellulose with 2% fucoidan solution lost their sorption capacity and antibacterial effect. In this case, in the wound development of microbial inflammation and excess of wound exudation were detected. This circumstance served as an indication for the change and re-application of coatings during treatment and as the basis for the choice of the14th day as an observation point (control date) to compare the results.