Invasive candidiasis is a serious complication in newborns. In the prospective study from January 2015 to July 2019 were included 31 neonates with “proven” IC according to the EORTC / MSG 2008 criteria, females - 58%. Premature neonates accounted for 87% of patients. Birth weight was from 560 to 4000 g (median - 1280 g), median gestational age at birth - 29 weeks (23 - 40). Broad-spectrum antibacterial drugs were prescribed in 100% patients, central venous catheter (CVC) - 93%, mechanical ventilation - 84%, parenteral nutrition - 71 %, blood transfusion - 55%. The main clinical variant of IC was candidemia - 97%, chorioretinitis (6%), meningitis (3%), and hepatitis (3%). The pathogens of IC were C. albicans - 45%, C. parapsilosis - 29%, and C. famata - 13%. In vitro resistant to fluconazole were 3% pathogens, dose-dependent susceptible to fluconazole - 6%. Fluconazole prophylaxis received 94% patients. In the first 24 hours after diagnosis, CVC was removed / replaced in 87% patients. In the first 24 hours after diagnosis, antifungal treatment was used in 100% patients: fluconazole (100%), micafungin (35%). The overall 30-day survival rate was 80,6%, the survival of three patients was unknown.