The development of respiratory complications in patients after surgical treatment of lung cancer remains a serious problem, far from being resolved today. Pain remains the main factor that leads to a decrease in respiratory function in the postoperative period.The aim of this study is to evaluate the effect of intrapleural lymphotropic blockades on the incidence of respiratory complications in the postoperative period in patients undergoing surgical treatment of lung cancer.Materials and methods. 103 patients with operable forms of lung cancer, who underwent anatomical lung resection or pneumonectomy, were treated in the Oncology Department of the Tomsk Regional Oncology Center. The patients were divided in two groups. The first group included 52 patients, who were supplemented with intrapleural lymphotropic blockades. The second group consisted of 51 patients who received a standard multimodal scheme of analgesia in the postoperative period. In the postoperative period, we assessed severity of pain in patients, and the frequency and types of respiratory disorders.Results. The analysis of the results revealed a significant decrease in the intensity of pain syndrome the first 12 hours after surgery in the group of patients, who underwent lymphotropic blockade. The analysis of the frequency of respiratory disorders in the study groups also revealed significant reduction in the number of complications in patients in the group with lymphotropic blockade. Acute postoperative pain, that prevents full natural ventilation, plays one of the key roles in the pathogenesis of respiratory complications in patients after surgical treatment of lung cancer.Conclusion. The use of multimodal analgesia of intrapleural lymphotropic blockade in the complex allows to reduce the pain syndrome and provide psycho-emotional comfort of the patient in the early postoperative period, thereby reducing the risk of respiratory disorders.