The paper presents the results of the use in the experiment of low-temperature cold atmospheric plasma in the treatment of third-degree skin burns (ICD-10). An original device was used to generate low-temperature plasma. The study was performed on 24 male rats weighing 230-250 g. Treatment of burn wounds was carried out with a plasma beam similar in nature to a positive corona discharge. The results of planimetric and morphometric studies were evaluated, taking into account the number of microvasculature vessels in the biopsy specimens of burn wounds on day 35 of observation. It was revealed that the implementation of early necrectomy with the use of low-temperature cold atmospheric plasma allows to increase the mass of newly formed vessels in a burn wound by 13.4%. The study of low-temperature cold atmospheric plasma reduces the frequency of purulent complications of burns, and also helps to reduce the time of recovery of the skin by 20%.