The aim of this study was to assess the impact of previously identified psychological risk factors of Internet addiction (IA) (non-planning impulsiveness, self-directedness and adverse childhood experiences associated with living in a community with a high level of violence) in carriers of preliminary genetic risk markers for IA (BDNF rs6265 (Val66Met ), NTRK3 rs2229910 and DRD4 exon 3 VNTR). The most important finding was related to the effects of childhood adverse experiences. They were manifested only in individuals without genetic risk markers for IA, and this could be considered as the first evidence of the association between genetic and psychological risk markers of IA in the framework of elaborating integrated risk markers. The fact that a specific association between psycho-traumatic childhood experiences and genetic risk markers of IA were identified for all three preliminary genetic risk markers of IA, suggests an important role of the gene-environment interactions in realizing the genetic risk for developing IA. In addition, we found that the protective effect of such a personality trait as self-directedness was realized only in carriers of the genetic risk marker for IA NTRK3 rs2229910, thus also evidencing the association between psychological and genetic risk markers for IA. We also confirmed a general negative effect of non-planning impulsiveness on the risk of IA, which was not associated with genetic risk markers of IA. Further research on larger samples will make it possible to form a system of integrated genetic and psychological markers of the risk for developing Internet addiction for prospective use in the framework of preventive measures.