Multiple birth pregnancy with fetal development and with the presence of partial molar pregnancy - is a rare phenomenon, whose incidence makes up 1 of 22000-100000 pregnancies [4]. However, lately scholarly literature has reported an increase of similar clinical cases, and termination of pregnancy right after the diagnosis is recommended in most cases. But some authors argue that approximately 40% of molar pregnancies with developing fetus result in successful outcomes without significant increase of the risk of subsequent process malignization [4,8]. This article presents the description of a clinical case of successful management and outcome of twin pregnancy in patient with partial molar pregnancy. Algorithm for diagnosis provided to exclude malignant process pursuant to the recommendations, as well as to exclude fetal malformations is demonstrated. The paper considers the viability to continue such pregnancy to term in case of its stable course, absence of markers of chromosomal abnormalities and fetal malformations evaluated using ultrasound, as well as in the event of patient’s extreme concernment for continuing pregnancy. The work also brings into focus the necessity of case follow-up, prevention and early detection of possible pregnancy complications. Delivery in the given clinical case occurred in the preterm stage due to spontaneous onset of early labor caused by existing isthmus and cervical insufficiency, outcome of this pregnancy was favorable for both mother and baby. Subsequently, the patient was followed-up by oncologist, the increase of ß-human chorionic gonadotropin (hCG) measurements was not observed.