Endometriosis is a gynecological disease highly associated with female infertility and is difficult to treat. In order to develop personalized therapy for endometriosis, it was important to study the ability of the endometrial cell line obtained from a patient with endometriosis to decidualize under various combinations of estradiol and hestagens under in vitro conditions. Combinations of estradiol with highly active progesterone analogs medroxyprogesterone and 17α-hydroxyprogesterone have been shown to be effective inducers of decidual transformation. The results obtained are a prerequisite for the development of personalized therapy for various gynecological diseases, including endometriosis, carried out using cellular technologies.