In this study, we analyzed distribution of nicotinic acetylcholine receptors, the degree of fragmentation of endplates and their area, and membrane localization of the Na,K-ATPase a2 isoform in the rat soleus muscle after functional unloading (the method of hindlimb suspension) for 1-3 days. After unloading, increased endplate fragmentation, accompanied by a decrease in the area of individual fragments was observed; the total area of the endplates was not changed. The distribution density of nicotinic acetylcholine receptors also remained unaltered, however, a significant decrease in the distribution density of the Na,K-ATPase a2 isoform was observed. Presumably, identified changes resulted from adaptive skeletal muscle remodeling, developing not only under chronic disorders, but even in the early stages of motor dysfunction.
Translated title of the contributionStructural and Functional Characteristic Features of Rat Soleus Endplates under Short-Term Disruption of Motor Activity
Original languageRussian
Pages (from-to)957-962
JournalБИОФИЗИКА
Volume64
Issue number5
StatePublished - Sep 2019

ID: 45290190