The objectives of the study were the analysis and generalization of the principles of developing models of socio-economic systems in relation to the management of a separate subject of the Russian Federation. Practical approaches to modeling the objects and processes of the region are presented. The questions of the correspondence of the levels of models to the levels of leaders in the hierarchy of the administration of the region are analyzed, approaches to the development and observance of temporary standards for data processing are presented. The questions of the choice of indicators used for modeling are considered, attention to the problems of ensuring the accuracy and reliability of management information is paid. The features of accounting in models of the influence of external conditions and the internal state of the system are analyzed. The approaches to determining the criteria for choosing options for managerial decisions, ensuring iteration in modeling long or branched processes are presented. The