The objective is to assess the safety of motor mapping using navigated transcranial magnetic stimulation (nTMS) in patients with brain tumors based on the literature data and own observations.Material and methods. The motor mapping with the help of navigated TMS was performed in 114 patients with supratentorial brain tumors. Side effects and complications, such as seizures, pain, hearing and cognitive changes during and after the procedure, were analyzed.Results. 101 (90.4 %) patients did not notice any discomfort during the study. There was not any cases of seizures during and after the procedure. 11 (9.6 %) patients experienced discomfort, 8 (72.3 %) patients of them noticed a slight headache.Conclusion. Navigated TMS is well tolerated in neurosurgical patients with tumors of the motor cortex.