The purpose of the study is to compare the effectiveness of IVF protocols with the use of corinollitropin alfa in women of advanced maternal age, depending on the ovarian reserve. Material and methods. Retrospective trial of infertile women (n=88) undergoing a single IVF/ICSI cycle with corifollitropin alfa. Depending on the age and state of the ovarian reserve, 3 groups of patients are formed. Group I (n=24) consisted of 37-42 years old women with a low ovarian reserve; group II (n=25) included patients of the same age with a normal ovarian reserve; the comparison group III (n=39) was formed from women 28-36 years with a normal ovarian reserve. Embryo transfer was performed in a fresh IVF cycle using GnRH antagonists protocols. Results. The duration of additional stimulation (from the 8th day of controlled ovarian stimulation) in I group was 6 (1-9), in II 3 (1-8) and in III 2 (1-4) days (p= 0.016; p=0.171). The total dose of additional stimulation of r-FSH in I group was 1687 (275-2650), in II 675 (200-1950