Introduction. Currently, the problem of infertility treatment has acquired not only medical, socio-demographic, but also economic importance. Overcoming infertility is currently carried out by modern high-tech methods of treatment — reproductive technologies (HRT), in which some or all stages of conception and early development of embryos are carried out outside the woman′s body. The standard variant of HRT is in vitro fertilization (IVF) — a medical technology of fertilization of women′s eggs in vitro with the husband′s (donor′s) sperm with subsequent transfer of the obtained embryos into the uterine cavity of the mother. However, the percentage of effectiveness of IVF programs is from 35 to 40 % and is due to the presence of high quality embryos in most cases uterine factor, which poses a challenge to clinicians to find and include new, primarily non-medicamentous, ways to treat patients with uterine form of infertility, which predetermined the purpose of this study. The aim of the study: study of the influence of including osteopathic correction in the complex treatment of patients with uterine form of primary female infertility under IVF protocol on the percentage of pregnancy and childbirth. Materials and methods. In a prospective randomized study conducted in the period from January 2020 to March 2024 based on the Medical Clinics LLC «Mokhov Institute of Osteopathy» (Saint-Petersburg), 70 people with a diagnosis of female infertility, primary, uterine form, who had 3 or more unsuccessful IVF attempts were included. All the participants of the study were divided into two groups — the main group and the control group of 35 people each. Patients of the main group along with standard drug therapy were given osteopathic correction, patients of the control group received only drug therapy according to the order № 107n from 30.08.2012 «On the procedure for the use of assisted reproductive technologies, contraindications and restrictions to their use». At the end of the treatment course, the osteopathic status, uterine blood flow parameters and the number of pregnancies and births were evaluated in the patients of the studied groups. Results. Patients with uterine form of primary female infertility were most often diagnosed with somatic dysfunctions of global and regional level. Somatic dysfunctions of the global (psychovisceral-somatic disorder — 28,6 %), and regional level (the dura mater region — 30 %, lumbar region visceral component — 15 %, pelvic region visceral component 18 %, thoracic region visceral component — 8,4 %) were determined as dominant. As a result of inclusion of osteopathic correction in the complex treatment of patients with infertility, the frequency of pregnancy resulting in childbirth statistically significantly increased. Conclusion. As part of the complex treatment of patients with uterine form of primary female infertility osteopathic correction in combination with the use of standard medical therapy as part of the IVF protocol contributes to a statistically significant increase in the number of pregnancies and born children compared to the use of an isolated standard IVF protocol in this category of patients.