Suppurative inflammatory intracranial complications of acute and chronic diseases of ear, nose and paranasal sinuses are the most severe and life-threatening pathology, the interest in it has been growing over the recent years, due to epidemiological and clinical features of these diseases, with the absence of clear algorithms for diagnostics and treatment of this group of patients. Today, the rates of hospital mortality and disability due to intracranial complications remain high, which is associated with diagnostic, tactical difficulties in providing specialized medical care to these patients. The article presents a clinical case of an interdisciplinary approach to the treatment of a patient with intracranial complications (meningoencephalitis, subdural empyema, severe sepsis associated with chronic acute polisinusitis exacerbation). The article provides a plan of complex examination of the patient, the tactics of surgical and conservative treatment of this patient.