The conflict between physician and patient associated with fungal contamination is the actual problem in clinical mycology. On the one hand, the patient not having the special and complete data about the nature of mycoses, worried about the detection at him opportunistic fungi, intends to take antifungal medication, on the other hand, the physician-mycologist who is informed about the possible side effects of antifungal drugs and the absence of the disease even upon detection of the potential causative agent of the mycosis. The conflict in this system, especially if the patient is neurotizated can be very serious. The article presents a list of the main possible side-effects of antifungal drugs and the basic techniques of resolution of emerging conflict through negotiations (Harvard method, maieutics) that can be used by the physician in dialogue with the patient.