Objective. The problem of finding ways of adequate relief of pain in patients with cancer is actively studied in contemporary science. The question of impact of pain on quality of life in cancer patients is also studied: the prevalence and intensity of pain significantly determine the overall assessment of patients’ quality of life. The article is devoted to study psychological factors influence on quality of life parameters related to pain perception and activity restrictions in oncoorthopedics. 139 Study participants were inpatients of N.N. Blokhin Russian Cancer Research Center. The diagnoses were osteosarcoma (42 persons), Ewing sarcoma (10 persons) giant cell tumor (32 persons), chondrosarcoma (32 persons) and bone metastases (23 persons). Materials and methods. The psychological methods were: «SF-36 Health Status Survey», Quality of Life Questionnary-Core 30 of European Organization for Research and Treatment Cancer with module Bone Metastases 22, questionnaires «BIG 5», «The ways of coping» and «Purpose-in-Life Test», questionnaire of relation to disease «TOBOL». Results. The results revealed patients with metastases asses their quality of life significantly lower than other patients and asses pain characteristics as more intensive. The most widespread pain is revealed in patients inclined to behavior determined as «irritable weakness» and gloomy mood. Conclusion. The study shows the need for individual approach, taking into account the personal profile in the choice of analgesic therapy in patients with musculoskeletal tumors, especially in cases of opioids treatment.