Introduction. The problem of chronic pelvic pain is due to the complexity of timely verification of the disease, due to its multidisciplinary nature, which in turn leads to the chronification of the process, steadily reducing the quality of life of patients. Despite the widespread use of both drug-based and non-drug-based approaches in the treatment of patients with chronic pelvic pain syndrome (CPPS), the effectiveness of treatment often remains low, requiring constant economic costs, this in turn reduces the patient′s commitment to treatment, placing clinicians with the challenge of finding and including new non-pharmacological ways to treat patients with this type of nomology in a comprehensive manner. The aim of the study: to study the results of osteopathic correction in the comprehensive treatment of patients with CPPS. Materials and methods. In a prospective randomized controlled study conducted between October 2023 and January 2025 at the Women′s Consultation № 7 Krasnodar Maternity Hospital. 50 women aged 20 to 40 years with CPPS were included. All patients were divided into two comparable groups of 25 people — the main and control group, depending on the treatment method used. Patients in the main group of the comprehensive treatment of CPPS along with standard therapy (use of non-steroidal anti-inflammatory drugs, physiotherapeutic procedures and exercises of curative physical culture) were carried out osteopathic correction (3 procedures with an interval of 13–16 days), the patients in the control group received only standard treatment without osteopathic correction. All subjects were given an osteopathic examination prior to and 2 weeks after completion of treatment, with the formation of an osteopathic conclusion and assessed the degree of severity of pain syndrome and quality of life. Results. Osteopathic correction in the complex treatment of patients with CPPS compared to standard therapy statistically significant (p