An understanding of the relationships psychosexual characteristics of psychophysiological and personal characteristics of women, patients with neurotic disorders, it has implications for positive pathogenic diagnosis and integrative psychotherapy of these disorders. The aim of the study was to study the dependence of gender-role behavior of women with neurotic disorders on the regulatory role of temperament. 94 women with neurotic disorders and 50 women without mental disorders were examined. Research methods: clinical, “the Questionnaire structure of temperament”, “ Methods for diagnostics of character accentuations gender-role behavior”. In the group of patients with neuroses, and in the group of healthy characteristics of temperament, contributing to the mental adaptation of the individual, more pronounced in women with masculine accentuation of m-f dimension and gender-role behavior, compared with women without accentuation. Differences between masculine women of the main and control groups show that this trend is more pronounced in the group of healthy women with higher rates of the main characteristics of temperament. It is shown that with age in women with neurotic disorders there is no radical change in the internal mechanisms of regulation of gender-role behavior: the replacement of biological mechanisms (temperament) on the socio-psychological (gender identity) in contrast to women without mental disorders. The close interrelation of temperament with gender-role behavior at all age stages of women with neuroses in comparison with healthy women at whom such connection is observed only in children is revealed.