TY - JOUR

T1 - БИОМАРКЕРЫ ОСТРОГО ГИПОКСИЧЕСКИ-РЕОКСИГЕНАЦИОННОГО ПОВРЕЖДЕНИЯ НЕФРОЦИТОВ В УСЛОВИЯХ ЛАПАРОСКОПИЧЕСКОЙ РЕЗЕКЦИИ РЕНАЛЬНОЙ ПАРЕНХИМЫ

AU - Popov, S V

AU - Guseinov, R G

AU - Martov, A G

AU - Muratov, T M

AU - Tabynbaev, N B

PY - 2017

Y1 - 2017

N2 - Intraoperative occlusion of the renal artery during laparoscopic partial nephrectomy results in warm ischemia and nonspecific hypoxia-reoxygenation alteration of the renal parenchyma cells with a predominant injury to epitheliocytes of the proximal segments of the tubular nephron system. The onset and development of acute kidney injury (AKI) syndrome, which requires immediate correction, is due to the typical pathological process of cell injury. In this regard, the issue of timely diagnosis of AKI remains highly relevant. In patients at high risk of developing acute renal failure, detection of AKI biomarkers enables early diagnosis. In cases with hypoxia-reoxygenation mediated destruction of epithelial cells of tt. renales, related to warm ischemia, the quality of diagnosis is significantly improved if the standard work-up is supplemented by measurements of the concentration and/or activity of cystatin C, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid binding protein, N-acetyl --glucosaminidase, glutathione S-transferase -isoform, -glutamyl transpeptidase and lactate dehydrogenase. This article provides an overview of published evidence on the properties and diagnostic capabilities of biomarkers of warm ischemia related AKI.

AB - Intraoperative occlusion of the renal artery during laparoscopic partial nephrectomy results in warm ischemia and nonspecific hypoxia-reoxygenation alteration of the renal parenchyma cells with a predominant injury to epitheliocytes of the proximal segments of the tubular nephron system. The onset and development of acute kidney injury (AKI) syndrome, which requires immediate correction, is due to the typical pathological process of cell injury. In this regard, the issue of timely diagnosis of AKI remains highly relevant. In patients at high risk of developing acute renal failure, detection of AKI biomarkers enables early diagnosis. In cases with hypoxia-reoxygenation mediated destruction of epithelial cells of tt. renales, related to warm ischemia, the quality of diagnosis is significantly improved if the standard work-up is supplemented by measurements of the concentration and/or activity of cystatin C, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid binding protein, N-acetyl --glucosaminidase, glutathione S-transferase -isoform, -glutamyl transpeptidase and lactate dehydrogenase. This article provides an overview of published evidence on the properties and diagnostic capabilities of biomarkers of warm ischemia related AKI.

KW - Acute Disease

KW - Biomarkers/metabolism

KW - Humans

KW - Laparoscopy/adverse effects

KW - Nephrectomy/adverse effects

KW - Reperfusion Injury/diagnosis

U2 - 10.18565/urology.2017.6.120-124

DO - 10.18565/urology.2017.6.120-124

M3 - Обзорная статья

C2 - 29376608

SP - 120

EP - 125

JO - УРОЛОГИЯ

JF - УРОЛОГИЯ

SN - 1728-2985

IS - 6

ER -