TY - JOUR

T1 - Первый опыт применения фиксированной комбинации левофлоксацина и кеторолака в хирургии катаракты

AU - Николаенко, Вадим Петрович

AU - Белов, Дмитрий Федорович

N1 - Export Date: 05 February 2026; Cited By: 0; Correspondence Address: D.F. Belov; City Multidisciplinary Hospital No. 2, St. Petersburg, 5, Uchebnyy Lane, 194354, Russian Federation; email: belovd1990@gmail.com

PY - 2025

Y1 - 2025

N2 - Purpose. To develop an algorithm for efficient and safe application of the fixed combination of levofloxacin and ketorolac (Signicef® Plus) for the prevention of infectious complications and excessive inflammatory response after phacoemulsification (PE). Materials and methods. The studу group consisted of 449 patients (500 eyes), examined on 6th and 15th day after uncomplicated PE of senile cataract. Prevention of infection and inflammation included instillations of Signicef® Plus QID over five days and 0.1 % solution of fluorometholone (Floace Mono) QID for two weeks since the day of the operation. Primary outcome — proportion of patients with zero inflammatory response in the anterior segment, secondary outcomes — incidence of acute endophthalmitis, ocular surface condition and tolerance of the fixed combination. Results. Among the studied patients there were no cases of acute iridocyclitis or endophthalmitis. No inflammatory response on the 6th and the 15th day was reported in 98.8 and 100 % of cases respectively. The fixed combination was well tolerated without having a negative effect on the ocular surface. Conclusions. The use of Signicef® Plus for five days and Floace Mono for two weeks appears to be an effective and safe tool for preventing infectious and inflammatory complications of PE. © 2025, Real Time LLC. All rights reserved.

AB - Purpose. To develop an algorithm for efficient and safe application of the fixed combination of levofloxacin and ketorolac (Signicef® Plus) for the prevention of infectious complications and excessive inflammatory response after phacoemulsification (PE). Materials and methods. The studу group consisted of 449 patients (500 eyes), examined on 6th and 15th day after uncomplicated PE of senile cataract. Prevention of infection and inflammation included instillations of Signicef® Plus QID over five days and 0.1 % solution of fluorometholone (Floace Mono) QID for two weeks since the day of the operation. Primary outcome — proportion of patients with zero inflammatory response in the anterior segment, secondary outcomes — incidence of acute endophthalmitis, ocular surface condition and tolerance of the fixed combination. Results. Among the studied patients there were no cases of acute iridocyclitis or endophthalmitis. No inflammatory response on the 6th and the 15th day was reported in 98.8 and 100 % of cases respectively. The fixed combination was well tolerated without having a negative effect on the ocular surface. Conclusions. The use of Signicef® Plus for five days and Floace Mono for two weeks appears to be an effective and safe tool for preventing infectious and inflammatory complications of PE. © 2025, Real Time LLC. All rights reserved.

KW - cataract

KW - fluorometholone

KW - ketorolac

KW - levofloxacin

KW - phacoemulsification

KW - postoperative examination

KW - floace mono

KW - signicef plus

KW - Article

KW - cataract extraction

KW - drug tolerance

KW - endophthalmitis

KW - human

KW - incidence

KW - iridocyclitis

KW - major clinical study

KW - outcome assessment

KW - postoperative complication

U2 - 10.21516/ 2072-0076-2025-18-1-48-54

DO - 10.21516/ 2072-0076-2025-18-1-48-54

M3 - статья

VL - 18

SP - 48

EP - 54

JO - Российский офтальмологический журнал

JF - Российский офтальмологический журнал

SN - 2072-0076

IS - 1

ER -