Speaking about the formation of semiotic conscious biology, it is important not to create a calendar plan of transformations, but to consider the points of bifurcation that will be passed. It is fundamental that such a formation implies the recognition of sign-making, and therefore of meaning, in living organisms. This can be realized through the reinterpretation of the synthetic theory of evolution in the categories of information theory, the development of biosemiotics based on the semioticses by Ch.S. Peirce and F. de Saussure, or the development of a biological sense (for example, in biohermeneutics). Any version of semiotic awareness of biology in an explicit form makes semantics a subject of natural science, which is a revolution in it for the first time after the declared radical overcoming of anthropomorphism in the 19th century. Such a revolution radically changes not only the sphere of knowledge, but also technology, thanks to the awareness of the existence of a wide class of semiotic biotechnologies, which can have a strong influence on NBIC-convergence. As a result of the reflection of the situation and the competition of biotechnology, a balance of biohermeneutics, biophilology, biolinguistics, bio-semiotics and biopragmalinguistics may emerge as variants of semiotically conscious biology.