The main tendencies in the development of Pathophysiology as a science and teaching discipline are analyzed in the light of last 6th ISP-2010 Congress. The witnesses for the growing integration between Pathophysiology and other basic medical sciences are given, along with the preserved specifics of the pathophysiological knowledge on the etiology, pathogenesis and models of the diseases and pathological processes. The current role and place of Pathophysiology as Systemic Pathobiology within the structure of medical sciences are discussed.