Practical recommendations are intended to optimize the tactics of managing patients with non-alcoholic fatty liver disease and are recommended for use by physicians working in the outpatient and inpatient health sectors of St. Petersburg, are intended for general practitioners and all specialists interested in clinical gastroenterology. These practical recommendations were developed on the basis of the approved Clinical Recommendations of the Ministry of Health of Russia “Medicinal liver damage”, approved by the Health Committee of the Government of St. Petersburg on October, 26, 2020.