Морфологические и молекулярные особенности метастазов аденокарциномы толстой кишки в печень

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Морфологические и молекулярные особенности метастазов аденокарциномы толстой кишки в печень. / Raskin, G. A.; Ivanova, A. K.; Mukhina, M. S.; Orlova, R. V.

In: АННАЛЫ ХИРУРГИЧЕСКОЙ ГЕПАТОЛОГИИ, Vol. 24, No. 4, 2019, p. 12-17.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{876ff600fd154050a7fbab16be75832e,

title = "Морфологические и молекулярные особенности метастазов аденокарциномы толстой кишки в печень",

abstract = "Aim. To study pathological and molecular features of liver metastases of colon adenocarcinoma. Material and methods. DNA mismatch repair (MMR), CXCR4 expression, Ki-67 proliferative activity were investigated in 125 cases of colon adenocarcinoma with liver metastases. First group consisted of 94 cases of tumor with liver metastases at diagnosis. The second group consisted of 31 cases with stage II disease at diagnosis, but subsequently these patient metastases. In second group KRAS mutation was investigated. The control group included 22 cases of stage II colon adenocarcinoma without disease progression. MMR was studied in 325 cases of colon adenocarcinoma without known stage. Results. MMR deficiency (dMMR) didn't revealed in group 1 and 2. The frequency of deficiency MMR in the general population of colon adenocarcinoma was 8%. Low level of expression of CXCR4 in group I and II was revealed in 16% of cases, in control group - in 73%. Low level of Ki-67 was revealed in 5% of cases of liver metastases (group 1 and 2), the frequency of KRAS mutations was 45%. Conclusion. Colon adenocarcinoma with liver metastases is characterized by aggressive immunophenotype: high expression rates CXCR4, Ki-67, and preferentially retained MMR function.",

keywords = "Adenocarcinoma, Colon, CXCR4, Ki-67, KRAS, Liver, MMR, MSH6",

author = "Raskin, {G. A.} and Ivanova, {A. K.} and Mukhina, {M. S.} and Orlova, {R. V.}",

year = "2019",

doi = "10.16931/1995-5464.2019412-17",

language = "русский",

volume = "24",

pages = "12--17",

journal = "АННАЛЫ ХИРУРГИЧЕСКОЙ ГЕПАТОЛОГИИ",

issn = "1995-5464",

publisher = "VIDAR Publishing House",

number = "4",

}

RIS

TY - JOUR

T1 - Морфологические и молекулярные особенности метастазов аденокарциномы толстой кишки в печень

AU - Raskin, G. A.

AU - Ivanova, A. K.

AU - Mukhina, M. S.

AU - Orlova, R. V.

PY - 2019

Y1 - 2019

N2 - Aim. To study pathological and molecular features of liver metastases of colon adenocarcinoma. Material and methods. DNA mismatch repair (MMR), CXCR4 expression, Ki-67 proliferative activity were investigated in 125 cases of colon adenocarcinoma with liver metastases. First group consisted of 94 cases of tumor with liver metastases at diagnosis. The second group consisted of 31 cases with stage II disease at diagnosis, but subsequently these patient metastases. In second group KRAS mutation was investigated. The control group included 22 cases of stage II colon adenocarcinoma without disease progression. MMR was studied in 325 cases of colon adenocarcinoma without known stage. Results. MMR deficiency (dMMR) didn't revealed in group 1 and 2. The frequency of deficiency MMR in the general population of colon adenocarcinoma was 8%. Low level of expression of CXCR4 in group I and II was revealed in 16% of cases, in control group - in 73%. Low level of Ki-67 was revealed in 5% of cases of liver metastases (group 1 and 2), the frequency of KRAS mutations was 45%. Conclusion. Colon adenocarcinoma with liver metastases is characterized by aggressive immunophenotype: high expression rates CXCR4, Ki-67, and preferentially retained MMR function.

AB - Aim. To study pathological and molecular features of liver metastases of colon adenocarcinoma. Material and methods. DNA mismatch repair (MMR), CXCR4 expression, Ki-67 proliferative activity were investigated in 125 cases of colon adenocarcinoma with liver metastases. First group consisted of 94 cases of tumor with liver metastases at diagnosis. The second group consisted of 31 cases with stage II disease at diagnosis, but subsequently these patient metastases. In second group KRAS mutation was investigated. The control group included 22 cases of stage II colon adenocarcinoma without disease progression. MMR was studied in 325 cases of colon adenocarcinoma without known stage. Results. MMR deficiency (dMMR) didn't revealed in group 1 and 2. The frequency of deficiency MMR in the general population of colon adenocarcinoma was 8%. Low level of expression of CXCR4 in group I and II was revealed in 16% of cases, in control group - in 73%. Low level of Ki-67 was revealed in 5% of cases of liver metastases (group 1 and 2), the frequency of KRAS mutations was 45%. Conclusion. Colon adenocarcinoma with liver metastases is characterized by aggressive immunophenotype: high expression rates CXCR4, Ki-67, and preferentially retained MMR function.

KW - Adenocarcinoma

KW - Colon

KW - CXCR4

KW - Ki-67

KW - KRAS

KW - Liver

KW - MMR

KW - MSH6

UR - http://www.scopus.com/inward/record.url?scp=85081360074&partnerID=8YFLogxK

U2 - 10.16931/1995-5464.2019412-17

DO - 10.16931/1995-5464.2019412-17

M3 - статья

AN - SCOPUS:85081360074

VL - 24

SP - 12

EP - 17

JO - АННАЛЫ ХИРУРГИЧЕСКОЙ ГЕПАТОЛОГИИ

JF - АННАЛЫ ХИРУРГИЧЕСКОЙ ГЕПАТОЛОГИИ

SN - 1995-5464

IS - 4

ER -

ID: 75175846