The study was conducted to identify the prevalence of malformations of the maxillofacial area and oral organs in children with congenital neuropsychiatric disorders and to determine their predictive properties in the formation of acquired dental diseases. The object of the study involved 277 children with neuropsychiatric pathology and 260 children without comorbid pathology. It was established that children with neuropsychiatric pathology had a high percentage of congenital pathology of the maxillofacial area and oral cavity in comparison with the control group. The identified orofacial anomalies can be classified as congenital morphological predictors of dental diseases, as they are well-known and proven risk factors for developing hard dental tissue diseases, periodontal disease, cheilitis, stomatitis, etc.