A Natural-technogenic system of Baskunchak Lake is a unique object, formed as a result of salt tectonics. In the catchment area of the lake there are two deposits (lake salt and gypsum), two lenses of balneological mud, and infrastructure objects. Apart from its importance as a deposit, the lake and its surrounding area have the status of a nature reserve of Federal signifi cance. Active salt domes, the raising of which led to the formation of the lake, are connected with Baskunchak Lake by underground water. In general, they are a part of a single natural system in which the raising of the domes is compensated by leaching of rock salt with underground water, and the lowering of the lake basin is equilibrated by evaporation and salt accumulation. Dynamic equilibrium of the entire system is maintained by tectonic, hydrogeological, geological and climatic processes. The article shows that the state of dynamic equilibrium can be disrupted due to the impact of anthropogenic factors, and describes the consequences of such disturbances. Th e paper includes the description of the methodology of the monitoring system required for the calculation of the natural resources of salt accumulation in the deposit. In conclusion, new methods of management of such natural-technogenic systems are offered.