The use of robotic systems (RSs) in future manned space missions requires the creation of the cosmonaut-researcher a holistic view on the forms of interaction within the “human - robot” system (HRS) under the adverse environmental conditions. For these purposes, educational and reference materials (ERMs) are needed in fields of ergonomics and its representation in the design of human-machine interfaces (HMI). The paper considers the application of the ontological approach in the actual subject area - the ergonomics of the HMI, as the way of interdisciplinary integration various scientific fields - Informatics, ergonomics, psychophysiology, etc.