The experience of creation, development, and application of hybrid technologies in the work of hospitals providing assistance to victims with severe concomitant trauma is analyzed. The reasons for the formation and the need to use a hybrid anti - shock operating room are described. The stages of the gradual introduction of hybrid technologies into surgical practice are disclosed. The results of using a hybrid operating room and different views on trauma care, difficulties arising in the course of work in the operating room are summarized. The modern approaches to the treatment of patients with severe concomitant trauma in a hybrid operating room are presented. The use of hybrid technologies creates the prerequisites for the creation of a new strategy for the treatment of polytrauma, which makes it possible to improve outcomes by reducing the time required for accurate diagnosis of injuries, a quick start of emergency surgery/resuscitation using both traditional open interventions and minimally invasive endovascular methods of hemostasis.