A modern civilization transformation necessitates a complex humanitarian expertise. The purpose of the article is to show significance and prospects for implementation of such expertise in the development and implementation of large-scale projects and programs. Modern socio-cultural practices have revealed the core, the main, if not the absolute criterion of humanitarian expertise. Such a core is the provision, preservation and development of subjectivity as the main factor and impetus for the development of human civilization, the main condition for its plasticity, pre-adaptation and pro-creativity. Its conceptual basis can be associated with an interdisciplinary approach based on social semiotics and its expansion into deep semiotics. This approach realizes the role and significance of the factor of personal subjectivity as a source, tool and result of semiosis of culture as generation, selection, storage and transmission of social experience. An example of this approach implementation is regional socio-cultural design. Such opportunities are represented by the works of famous culturologists V. I. Bakshtanovsky, I. E. Fadeeva, and V. A. Sulimov. A special consideration is devoted to the project of the Ethno-park of Finno-Ugric Culture in the Komi Republic aimed at solving a large-scale set of tasks - from development of human and social capital and educational and recreational goals to promoting the image and reputational potential of the region. This project is the promise of realization of the desired experiences, a unifying, attractive idea rooted in the past, comprehending the present, responding to deep aspirations, hopes, opening up new horizons for future development. Thus, the work demonstrates possibilities of social semiotics, humanitarian expertise, not only in scientific and theoretical, but also in practical terms including socioeconomic development on a regional scale.