Objective - to describe the current geoepidemiology, clinical and laboratory features of imported transmissible infections in Saint-Petersburg. Material and methods. The study included 86 patients with dengue fever, 90 patients with malaria and 2 patients with West Nile fever admitted to Clinical Infectious Diseases Hospital named after S.P. Botkin, Saint Petersburg, Russia, in 2012-2018. Results. Among the imported transmissible infections in Saint Petersburg, the most prevalent are tropical and tertian malaria, dengue fever, and sporadic cases of West Nile fever. Most often these diseases are imported from Central and West Africa, Asia (mostly Thailand) and India. In our study, the clinical and laboratory features of malaria, dengue fever and West Nile fever consisted with classical description of clinical course of these infections. All patients with dengue fever and West Nile fever were diagnosed with moderate severity classical form of disease with good outcome. In most cases of tertian malaria, the moderate severity form was also diagnosed. A lack of schizontocidal antimalarial drugs resulted in 13 cases of tertian malaria relapses. In 2016, one case of tropical malaria was acquired in a medical facility representing transfusion-transmitted or needle-stick injury malaria. Significant increase of number of tropical malaria cases was observed in 2018. Severe form of tropical malaria was observed in 31.4% of cases with 1 fatal case in a patient with complex comorbidity. Conclusion. In Saint Petersburg, the number of imported transmissible diseases is increasing predominately due to tropical malaria. In case of postponed diagnosis and severe comorbidity, diseases may have severe course with increased mortality. Our work demonstrates the importance of appropriate collection of epidemiological anamnesis and travel history data at all levels of medical help. Imported transmissible diseases need to be included in differential diagnosis of acute febrile illnesses.