Studying quality of life and its factors as well as the impact of quality of life on the outcomes of treatment and postoperative rehabilitation is important due to significant progress in the treatment of patients with primary and metastatic bone tumor. This study continues series of works of the authors in this area. The study is devoted to reveal relationship between the main parameters of quality of life and survival in patients with bone tumors. The data of psychological study in 50 patients with bone tumors were compiled. The EORTC QLQ-C30 (Quality of Life Questionnaire Core-30) and BM-22 (additional module) were used to study the main parameters of quality of life. Patient survival was calculated using Kaplan-Meier method. According the results, higher quality of life among patients with bone tumors correlates with better survival, while decreased quality of life in patients, manifested in the somatization of negative emotional experiences, is associated with a lower level of survival. In accordance with the results obtained in the framework of a multidisciplinary approach to the treatment and rehabilitation of patients with bone tumors, the main directions of psychological assistance in the oncoortopedic clinic are done.