Прогностическое значение клинико-морфологических и молекулярно-биологических характеристик аденокарциномы толстой кишки

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Прогностическое значение клинико-морфологических и молекулярно-биологических характеристик аденокарциномы толстой кишки. / Raskin, G. A.; Pozharissky, K. M.; Orlova, R. V.; Petrov, S. V.

In: АРХИВ ПАТОЛОГИИ, Vol. 77, No. 5, 2015, p. 26-30.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{5e7fefe66b9347f08994764ddee257d9,

title = "Прогностическое значение клинико-морфологических и молекулярно-биологических характеристик аденокарциномы толстой кишки",

abstract = "Objective: to estimate the predictive and prognostic factors using morphological studies in patients with colon cancer to increase survival rates. Subjects and methods: Immunohistochemical examination was made in 582 patients with colon adenocarcinoma, by determining 11 different indicators relating to the development of the tumor and its treatment. Results: The simultaneous determination of the chemokine receptor CXCR4 and proliferative activity (Ki-67 expression) can define disease prognosis in view of relapse-survival rates in patients with Stage II colon cancer after radical surgical treatment. Conclusion: Thymidylate synthase and thymidine phosphorylase are of predictive value. The immunohistochemical examination of other markers, such as ALDH1, CCR10, ERCC-1, DYPD, topoisomerase II alpha, and class III beta-tubulin for the choice of treatment policy for patients with colon cancer has indicated that they are of no value.",

keywords = "ALDH1, Colon cancer, CXCR4, Ki-67",

author = "Raskin, {G. A.} and Pozharissky, {K. M.} and Orlova, {R. V.} and Petrov, {S. V.}",

year = "2015",

doi = "10.17116/patol201577526-30",

language = "русский",

volume = "77",

pages = "26--30",

journal = "АРХИВ ПАТОЛОГИИ",

issn = "0004-1955",

publisher = "Медиа Сфера",

number = "5",

}

RIS

TY - JOUR

T1 - Прогностическое значение клинико-морфологических и молекулярно-биологических характеристик аденокарциномы толстой кишки

AU - Raskin, G. A.

AU - Pozharissky, K. M.

AU - Orlova, R. V.

AU - Petrov, S. V.

PY - 2015

Y1 - 2015

N2 - Objective: to estimate the predictive and prognostic factors using morphological studies in patients with colon cancer to increase survival rates. Subjects and methods: Immunohistochemical examination was made in 582 patients with colon adenocarcinoma, by determining 11 different indicators relating to the development of the tumor and its treatment. Results: The simultaneous determination of the chemokine receptor CXCR4 and proliferative activity (Ki-67 expression) can define disease prognosis in view of relapse-survival rates in patients with Stage II colon cancer after radical surgical treatment. Conclusion: Thymidylate synthase and thymidine phosphorylase are of predictive value. The immunohistochemical examination of other markers, such as ALDH1, CCR10, ERCC-1, DYPD, topoisomerase II alpha, and class III beta-tubulin for the choice of treatment policy for patients with colon cancer has indicated that they are of no value.

AB - Objective: to estimate the predictive and prognostic factors using morphological studies in patients with colon cancer to increase survival rates. Subjects and methods: Immunohistochemical examination was made in 582 patients with colon adenocarcinoma, by determining 11 different indicators relating to the development of the tumor and its treatment. Results: The simultaneous determination of the chemokine receptor CXCR4 and proliferative activity (Ki-67 expression) can define disease prognosis in view of relapse-survival rates in patients with Stage II colon cancer after radical surgical treatment. Conclusion: Thymidylate synthase and thymidine phosphorylase are of predictive value. The immunohistochemical examination of other markers, such as ALDH1, CCR10, ERCC-1, DYPD, topoisomerase II alpha, and class III beta-tubulin for the choice of treatment policy for patients with colon cancer has indicated that they are of no value.

KW - ALDH1

KW - Colon cancer

KW - CXCR4

KW - Ki-67

UR - http://www.scopus.com/inward/record.url?scp=84973409590&partnerID=8YFLogxK

U2 - 10.17116/patol201577526-30

DO - 10.17116/patol201577526-30

M3 - статья

C2 - 26978017

AN - SCOPUS:84973409590

VL - 77

SP - 26

EP - 30

JO - АРХИВ ПАТОЛОГИИ

JF - АРХИВ ПАТОЛОГИИ

SN - 0004-1955

IS - 5

ER -

ID: 39207310